Understanding of Factors Associated with Reporting to the Police, Helping Seeking, and Adopting in Self-protection among Stalking Victims: A Latent Class Analysis.

Victims of stalking use multiple help-seeking behaviors including reporting their experiences to the police, obtaining a restraining order, blocking communication, and relying on informal social networks like friends, family, or therapists. The goal of this study is to, first, identify distinct subgroups of stalking victims based on their help-seeking behaviors. Next, we identify the direct effect of sex, victim-offender relationship, and offense severity on class membership. Finally, we include negative emotions as a mediating effect. Using the 2016 National Crime Victimization Survey's Supplemental Victimization Survey data, latent class analysis was utilized to identify class membership among 1,459 stalking victims. The results indicate three groups: passive help-seekers, informal help-seekers, and active help-seekers. We found that females are more likely to be assigned to the active or informal group and these two groups appear to experience more severe stalking behaviors compared to the passive group. Specifically, victims were less likely to ask for help actively and ask family, friends, and non-professional people for help for whom stalking took place by other/unable to identify individuals. Victims whose stalkers had a criminal record, whose stalkers threatened themselves or others, as well as who suffered stalking lasting for months and the most often were more likely to ask for help actively and ask family, friends, and non-professional people for help. The significance of victims' perceptions of severity of both groups is only partially mediated by negative emotions.

Las víctimas del acoso utilizan diversos comportamientos de búsqueda de ayuda, como denunciar los hechos a la policía, conseguir una orden de alejamiento, bloquear la comunicación o confiar en las redes sociales informales como amigos, familia o terapeutas. El objetivo del estudio es en primer lugar reconocer distintos subgrupos de víctimas de acoso en función de sus comportamientos de búsqueda de ayuda. A continuación observamos el efecto directo en la pertenencia al grupo del sexo, la relación víctima-agresor y la gravedad del delito. Por último, abordamos el efecto mediador de las emociones negativas. Utilizando los datos de la encuesta suplementaria de victimización de la Encuesta Nacional de Delitos de Victimización de 2016 nos servimos del análisis de clases latentes para analizar la afiliación de clase en 1,459 víctimas de acoso. Los resultados muestran tres grupos: buscadores de ayuda pasivos, informales y activos. Resultó que es más probable que las mujeres sean asignadas al grupo activo o informal y que estos dos grupos parecen experimentar comportamientos de acoso más graves en comparación con el grupo pasivo. En concreto era menos probable que las víctimas pidieran ayuda activamente y a la familia, amigos y personas no profesionales que habían sufrido acoso por parte de otras personas incapaces de identificar. Era más probable que las víctimas cuyos acosadores tenían antecedentes penales y les habían acosado a ellos o a otras personas y cuyo acoso había durado meses y más a menudo pidieran ayuda activa y también a la familia, amigos y personas no profesionales. La importancia de cómo percibían la gravedad ambos grupos solo estaba mediatizada en parte por las emociones negativas.

Understanding of Factors Associated with Reporting to the Police, Helping Seeking, and Adopting in Self-protection among Stalking Victims: A Latent Class Analysis / [Conocer los factores asociados a las denuncias a la policía, la búsqueda de ayuda y la adopción de autoprotección en las víctimas de acoso: un análisis de clases latentes]

Victims of stalking use multiple help-seeking behaviors including reporting their experiences to the police, obtaining a restraining order, blocking communication, and relying on informal social networks like friends, family, or therapists. The goal of this study is to, first, identify distinct subgroups of stalking victims based on their help-seeking behaviors. Next, we identify the direct effect of sex, victim-offender relationship, and offense severity on class membership. Finally, we include negative emotions as a mediating effect. Using the 2016 National Crime Victimization Survey’s Supplemental Victimization Survey data, latent class analysis was utilized to identify class membership among 1,459 stalking victims. The results indicate three groups: passive help-seekers, informal help-seekers, and active help-seekers. We found that females are more likely to be assigned to the active or informal group and these two groups appear to experience more severe stalking behaviors compared to the passive group. Specifically, victims were less likely to ask for help actively and ask family, friends, and non-professional people for help for whom stalking took place by other/unable to identify individuals. Victims whose stalkers had a criminal record, whose stalkers threatened themselves or others, as well as who suffered stalking lasting for months and the most often were more likely to ask for help actively and ask family, friends, and non-professional people for help. The significance of victims’ perceptions of severity of both groups is only partially mediated by negative emotions.(AU)

Las víctimas del acoso utilizan diversos comportamientos de búsqueda de ayuda, como denunciar los hechos a la policía, conseguir una orden de alejamiento, bloquear la comunicación o confiar en las redes sociales informales como amigos, familia o terapeutas. El objetivo del estudio es en primer lugar reconocer distintos subgrupos de víctimas de acoso en función de sus comportamientos de búsqueda de ayuda. A continuación observamos el efecto directo en la pertenencia al grupo del sexo, la relación víctima-agresor y la gravedad del delito. Por último, abordamos el efecto mediador de las emociones negativas. Utilizando los datos de la encuesta suplementaria de victimización de la Encuesta Nacional de Delitos de Victimización de 2016 nos servimos del análisis de clases latentes para analizar la afiliación de clase en 1,459 víctimas de acoso. Los resultados muestran tres grupos: buscadores de ayuda pasivos, informales y activos. Resultó que es más probable que las mujeres sean asignadas al grupo activo o informal y que estos dos grupos parecen experimentar comportamientos de acoso más graves en comparación con el grupo pasivo. En concreto era menos probable que las víctimas pidieran ayuda activamente y a la familia, amigos y personas no profesionales que habían sufrido acoso por parte de otras personas incapaces de identificar. Era más probable que las víctimas cuyos acosadores tenían antecedentes penales y les habían acosado a ellos o a otras personas y cuyo acoso había durado meses y más a menudo pidieran ayuda activa y también a la familia, amigos y personas no profesionales. La importancia de cómo percibían la gravedad ambos grupos solo estaba mediatizada en parte por las emociones negativas.(AU)

Long-Term Relationships Between Negative Life Events and Suicidal Ideation Specifying Agnew's General Theory of Crime and Delinquency: A 7-Year Longitudinal Mediation Analysis.

The purpose of this study was to examine the longitudinal mediationa(l pathways on the link between various straining experiences and suicidal ideation and to test whether its relationship was mediated by the role of negative emotions, constraints, and motivations. Data for this study were collected as part of the Korean Welfare Panel Study, which was a longitudinal study conducted among 7,027 Korean households, surveyed annually from 2006 to 2012. The results indicated that bullying victimization had important effects on negative emotions, although bullying victimization was not significant for later suicidal ideation. Peer delinquency was significantly correlated with negative emotions and positively predicted later suicidal ideation. Also, the significant impact of bullying victimization was transmitted to suicidal ideation through negative emotions. It implies that individuals' negative life events predicted strain or stressors generating negative emotions that, in turn, led to a high risk of suicidal ideation as a possible coping skill.

Child abuse and individual traits related to developmental trajectories of bullying victimization: An integrated, multitheoretical approach.

INTRODUCTION: Adolescents who experience prior victimization such as child abuse within the home and experience low self-esteem/depression are at higher risk of repetitive bullying victimization when compared to those without such experiences. Recent scholarship has explored growth trajectories of bullying during adolescent development; however, relatively little is known about distinct trajectory patterns of bullying victimization across adolescent development. The current study identifies unobserved subgroups thus capturing the heterogeneity in developmental pathways in bullying victimization. METHOD: The current study uniquely utilized a multitheoretical approach to help explain the phenomenon of bullying victimization among a national sample of 2,190 youth in South Korea from 2010 to 2016. Theories tested include the integrated approach of target congruence, lifestyle and routine activities theories (LRAT), and the state dependence and population heterogeneity perspectives. To conduct this analysis, we performed a three-step latent class growth analysis. RESULTS: The study revealed three distinct trajectory groups. Korean adolescents who had higher levels of low self-esteem demonstrated greater odds of belonging to both the early-onset and decreasing and increasing and late peak groups. Those who had low-self-esteem and were depressed demonstrated greater odds of belonging to the early-onset and decreasing group. Prior experience of child abuse for the early-onset and decreasing group was fully mediated by the measures of target congruence and lifestyles. CONCLUSION: The current study contributes to research on developmental victimization by demonstrating the utility of integrating target congruence variables with lifestyle-routine activity concepts in explaining heterogeneity.

Explaining the Patterns of Bullying Victimization Trajectories: Assessing the Generality of Low Self-Control and Crime Opportunity Models to Bullying Victims.

This study hypothesizes that self-control and opportunity variables affect heterogeneity in developmental trajectories of bullying victimization. Using data from a follow-up study of 2,351 Korean adolescents, the study incorporates a latent class growth analysis approach to identify subgroups, each with a unique pattern of the trajectories. The model yields three subgroups of bullying victims: the early-onset and decreaser, the increaser and late-peak, and the normative groups. Results suggest that, compared to the normative group, the early-onset and decreasing group members manifest lower levels of self-control and engage in a greater range of delinquent behaviors. Also, the impact of low self-control on group membership was attenuated after controlling for those opportunity variables, indicating a partially mediating relationship. Social guardianship variables distinguished normative groups from other victim groups. Further, members of the increaser and late-peak group were more likely than the early-onset and decreaser group members to engage in cyber deviance over the long-term.

The Impact of Life Domains on Delinquent Behaviors in Five Caribbean Countries: A Partial Test of Agnew's General Theory of Crime and Delinquency.

The current study tests the applicability of Agnew's (2005) general theory of crime and delinquency to a sample of Caribbean Community (CARICOM) youths and explains the hypothesized direct and indirect/mediated effects of family attachment and peer delinquency on delinquent behaviors. Data for this study were obtained from a 2014 cross-sectional survey of 512 adolescents from the five members of the CARICOM. This study utilizes mediation analysis. Results reveal that adolescents with abuse experience from family members and unsafe school environments are more likely to engage in delinquent behavior. Furthermore, peer delinquency is significantly related to delinquent behavior and mediates the link between child abuse, family history of violence, unsafe school environment, and subsequent delinquent behavior. Finally, child abuse generated a lower level of family attachment, and then a higher level of family attachment led to a lower likelihood of subsequent delinquent behavior.

The Impact of Life Domains on Developmental Trajectories of Peer Delinquency among Korean Adolescents: A Partial Test of Agnew's General Theory of Crime and Delinquency with a Group-Based Trajectory Modeling Approach.

Agnew introduced a new integrated theory; the General Theory of Crime and Delinquency, in which he attempted to corral the most influential predictors of criminal behavior into more parsimonious propositions of multiple life domains-self, family, peer, school, and work-as well as constraints against crime and motivations for it. This study presents a partial test of the theory using longitudinal data of 2,351 Korean adolescents. A group-based modeling approach (latent class growth analysis) was run to examine direct effects of life domains on peer delinquency as well as mediating effects of constraints and motivation on their relationships. The study identified three subgroups: early onset/decreasing (3.2%), moderate (12.4%), and low/none (84.4%). The findings revealed that the self and peer domains exhibited a positive impact on the early onset/decreasing trajectory group compared to the low/none group with the constraint exhibiting a negative impact. The moderate trajectory group demonstrated that the self-domain was significant but was not rendered insignificant after controlling for constraints and motivations. The study provided moderate support for life domains within Agnew's new theory for peer delinquency in nonwestern countries.

Children's behavior problems, caregivers' trauma history, and membership in latent physical abuse trajectory classes: An approach of latent class growth analysis to dating violence victimization.

BACKGROUND: Child abuse is a serious social problem in the USA as many children suffer from child abuse and its negative consequences are severe. To prevent future victimization, it is essential to understand unique patterns of child abuse trajectories over time and the factors associated with their victimization. OBJECTIVE: The primary goal of this study was to identify individual differences in developmental trajectories of alleged physical abuse between the ages of 2 and 12. PARTICIPANTS AND SETTING: The sample included all children drawn from Longitudinal Studies of Child Abuse and Neglect (LONGSCAN), which is a consortium of five study sites (South, East, Midwest, Northwest, and Southwest). METHODS: Using the high-risk sample with Child Protective Service record reviews prior to age 4, significant variability in trajectory class membership was observed in the unconditional Latent Class Growth Analysis. RESULTS: Three trajectory classes were obtained from the data: Early Onset, Late Peak and Non-Victims. The findings showed that children who had an attention problem at age 4 were more likely to become members of both the Early Onset and Late Peak groups, relative to Non-victims. Also, membership in the Late Peak group was predicted by caregivers' childhood physical abuse, supporting for the cycle of physical abuse across generations. Finally, children in the Late Peak group were at the highest risk of being physically, psychologically, and sexually abused in a dating relationship at age 14. CONCLUSIONS: These results suggest that children's internal and external behavior problems and caregivers' childhood physical abuse are predictive of child abuse trajectory class membership. Parental education programs that increase their knowledge about children with special needs and intervention programs targeting caregivers with a history of physical abuse would be beneficial to prevent child abuse (re)victimization.

Influences of target congruence and lifestyles on victimization trajectories: An Autoregressive Latent Trajectory Modeling approach to overlap between bullying and victimization.

INTRODUCTION: Relative to the general victimization literature, a small body of literature has examined the longitudinal process of overlap between bullying perpetration and bullying victimization. To address this gap, this study assesses the dynamic process of bullying perpetration and victimization from a developmental perspective and examine the applicability of target congruence and lifestyle-routine activities approach. METHODS: Using data from 2,378 Korean youths collected from 2012 to 2016, the current study has conducted a Parallel Process Latent Growth Curve Modeling (PPLGCM) analysis to examine co-development and sequentially contingent processes of bullying and victimization, and Autoregressive Latent Trajectory Modeling (ALTM) to examine the time-lagged effect of bullying on victimization. RESULTS: Results from the PPLGCM revealed a significant and positive relationship between the initial levels of bullying and victimization as well as a reciprocal and cumulative influence over time. The ALTM analysis indicated that increased victimization in the previous year was associated with increased victimization in the following year. Further, time-concurrent and time-lagged effects of bullying on victimization were significant and positive. Finally, target congruence and risky lifestyle variables predicted the longitudinal process of victimization, indicating the cross-cultural generalizability of the theory. CONCLUSIONS: The findings offer support for a complex and dynamic relationship between bullying and victimization, and thus call for developmentally sensitive prevention strategies.

Functions of parenting styles on patterns of general and serious delinquency trajectories: A mediated model of school climates and delinquent peer association.

INTRODUCTION: This study partially tests Agnew's (2005, 2011) general theory of crime and delinquency, drawing out the differential roles of parenting, constraints, and motivations when comparing general delinquency trajectories and serious delinquency trajectories. METHODS: Using data from a 7-year follow-up study of 927 South Korean male adolescents, the study incorporates a group-based trajectory modeling to identify subgroups, each having a unique pattern of trajectories, respectively. RESULTS: The models yielded 3 subgroups: Early onset & decreaser, Increaser & late peak, and Normative for general delinquency as well as Serious delinquent, Moderate delinquents, and Normative for serious delinquency. The results reveal that compared to Normative group, parenting styles were significant of both the Moderate and Serious delinquents groups for only serious delinquency even after controlling for constraints and motivations. The odds of belonging to both the Early-Onset & Decreaser and Increaser & Late Peak groups for general delinquency and the Moderate Delinquents group for serious delinquency were significantly higher for those who more frequently associated with delinquent peers. Depression was significant among members of the Early-Onset & Decreaser group, while school connectedness was significant among members of the Increaser & Late Peak group for general delinquency. There were no mediating role of constraints and motivations in the parent-delinquency prediction. CONCLUSIONS: Intervention programs aimed at improving parenting skills can be developed to decrease the likelihood of delinquency.

Impacts of Low Self-Control and Delinquent Peer Associations on Bullying Growth Trajectories Among Korean Youth: A Latent Growth Mixture Modeling Approach.

The emergence of studies applying Gottfredson and Hirschi's (1990) self-control theory to offending behaviors has produced empirical support confirming the position that individuals with low self-control are more likely to engage in deviant behaviors. However, few have examined its effects with opportunity factors. The present study examines the time-invariant effect of low self-control, as well as the time-concurrent and lagged effects of opportunity factors (parental attachment and delinquent peer associations), on bullying growth trajectories. The findings in the latent growth curve analysis demonstrate that low self-control is significantly related to both the initial levels and change in bullying over time, even after controlling for delinquent peer associations in homogeneous populations. The new approach described within the latent class growth modeling framework (i.e., growth mixture) incorporates a categorical latent trajectory variable representing latent classes (i.e., distinct subgroups), having similar patterns of bullying growth trajectories. Three groups of students emerged from the student-reported data at five time points from ages 11 to 15, decreasers (90%), moderate late peakers (7%), and high late peakers(3%), defined by different predictors and sequelae. Low self-control was rendered insignificant for both moderate late peakers and high late peakers relative to decreasers; delinquent peer associations had a time-concurrent effect for moderate late peakers than decreasers; and high late peakers had a time-lagged effect relative to moderate late peakers.

Stressful Life Events and Negative Emotions on Delinquency Among Korean Youth: An Empirical Test of General Strain Theory Assessing Longitudinal Mediation Analysis.

The current study examines the extent to which the argument of Agnew's general strain theory extends to a sample of South Korean youth to be able to explain the hypothesized direct and indirect/mediated effects of negative emotions derived from various negative life experiences of strain on delinquent behaviors. These experiences can include bullying victimization, parental abuse, poor friend quality, and poor physical functioning. Data for this study were compiled from the Korean Welfare Panel Study (KOWEPS), which is a longitudinal study among 7,027 Korean households surveyed from 2006 through 2012. This study utilizes the longitudinal mediation models for temporal precedence. Results reveal that adolescents with poor-quality friends during the previous year are more likely to engage in later delinquency, and adolescents who experience bullying victimization, child abuse, and poor friendship quality during the previous year are more likely to later feel negative emotions. Furthermore, early feelings of negative emotions are significantly related to later delinquent behaviors and partially mediate the link between poor friend quality and later delinquent behaviors. Finally, bullying victimization, child abuse, and poor friend quality generated negative emotions, which led to a greater likelihood of delinquent behavior later.

Examining the Mediating Effects of Negative Emotions on the Link between Multiple Strains and Suicidal Ideation: A Longitudinal Analysis.

Research suggests that various strains contribute to suicidal ideation, and the source of strain often indirectly affects suicidal ideation through negative affective states. The current study examines if the mediating effects of negative emotions from multiple strains is non-0, and the extent to which negative emotions transmis the effect of multiple strains on suicidal ideation. Self-reported data from a sample of Korean youth are analyzed in the mediation tests conducted here. Results indicate that bullying victimization, child abuse, and peer conflict have a direct effect on suicidal ideation in the causal steps analysis. However, the direct effects disappear when using the causal steps approach, which accounts for the mediating effect of negative emotions. Overall, it appears that various strains indirectly affect suicidal ideation through negative emotions. Implications and directions for future research are discussed.

Physcion reduces lipid accumulation and prevents the obesity in mice.

BACKGROUND: Obesity increases the risk of metabolic dysfunction such as dyslipidemia, hypertension, and fatty liver. Physcion (PY) is an anthraquinone that reportedly has anti-inflammatory and anti-bacterial properties. However, few studies have addressed the effect of PY on high-fat diet-induced obesity in mice. The purpose of this study was to investigate the effects of PY on obesity. METHODS: Male C57BL/6 J mice were randomly divided into three groups and fed normal diet (ND, 5% fat, w/w), high-fat diet (HFD, 20% fat, 1% cholesterol, w/w), and HFD supplemented with 0.002% PY (w/w) for 16 weeks. Obesity-related biomarkers were analyzed including whole body and white adipose tissue (WAT) weight, in addition to lipid and inflammatory factors in the plasma, feces, liver and epididymal WAT. Significant differences among the groups were determined using Student's t-test. Differences were considered statistically significant at p < 0.05. RESULTS: Body and WAT weights were significantly decreased by the PY supplement relative to the HFD groups. Energy expenditure was enhanced by the PY supplement, which led to ameliorate plasma lipids, adipokines, cytokines, and fecal lipids. Fatty acid (FA) synthesis decreased in the liver, while FA oxidation increased. Finally, lipid synthesis markedly decreased whereas lipolysis and oxidation increased in WAT. CONCLUSIONS: The PY supplement suppressed lipid accumulation in WAT and the liver by regulating enzyme and gene levels. These results indicate that PY can improve diet-induced obesity and its complications such as dyslipidemia, hepatic steatosis, and inflammation.

The Mediating Effect of Social Controls on Marijuana Use Among Adolescent Bullies, Victims, and Bully-Victims: A Comparison of Various Approaches to Mediation.

This study examines the impact of social control measures (e.g. parental attachment and prosocial peer attachment) on marijuana use among adolescents who were pure bullies, pure victims, and bully-victims. Data from the Health Behavior in School-Aged Children survey was utilized and consisted of a nationwide cross-section of 12,642 adolescents. Results revealed that adolescents who were pure bullies and bully-victims were more likely to use marijuana. Additionally, parental and peer attachments were significant in decreasing the likelihood of marijuana use for two of the bullying statuses (pure bullies and bully-victims). Further, the social control measures partially mediated the relationship between two of the bullying statuses and marijuana use despite having no significant relation of bullying victimization to marijuana use. Considering that parental and peer attachments had significant and direct effects on adolescent marijuana use in the predicted (inverse) direction, prevention programs should focus on building and strengthening these relationships as a means of reducing deviant behaviors such as marijuana use among adolescents.

Antiobesity Effects of Short-Chain Chitosan in Diet-Induced Obese Mice.

Dietary chitosan is known for its antiobesity effects by combining with bile acid and lipid droplets. When the chitosan structure is broken into short chains, the fat-binding capacity increases. The aim of this study was to compare long-chain chitosan (LC) with short-chain chitosan (SC) for their antiobesity effects in high-fat diet (HFD)-induced obese C57BL/6J mice for 12 weeks. The body weights of mice in both chitosan groups were decreased, especially in the SC group compared with the LC group. Total white adipose tissue and visceral fat weights were also decreased in mice of the SC group more than those of the HFD group. Moreover, SC supplementation lowered plasma triglyceride (TG) and cholesterol levels, whereas LC only lowered plasma free fatty acid level. Fecal lipids were increased in mice of both LC and SC groups, and hepatic TG and cholesterol levels were decreased in both groups. SC lowered phosphatidate phosphohydrolase activity and elevated ß-oxidation in the liver. Furthermore, SC decreased the expression of the hepatic lipid-regulating genes, including fatty acid synthase, peroxisome proliferator-activated receptor (PPAR)γ1, and PPARγ2; and increased the expression of carnitine palmitoyl transferase 1α and peroxisome proliferator-activated receptor γ coactivator (PGC)1α genes. In conclusion, we demonstrated that long-term supplementation of SC can ameliorate body weight and lipid levels by increasing lipid excretion and regulating lipid metabolism, including some enzyme activities and gene expression levels, in HFD-induced obese mice.

Peer victimization and substance use among African American adolescents and emerging adults on Chicago's Southside.

Urban African-American youth residing in poorly resourced communities are at a heightened risk of peer victimization, which consequently increases their likelihood of risky behaviors such as substance use. The present study examined whether there was a direct relationship between peer victimization and substance use and whether it was mediated by negative peer norms, internalizing problems, and bullying perpetration. African-American youth (n = 638) completed a self-administered questionnaire on age, biological sex, socioeconomic status, lifetime substance use, peer victimization and bullying perpetration, negative peer norms, and internalizing problems. There were no direct effects between peer victimization and substance use. However, negative peer norms and bullying were both independently associated with substance use, although internalizing problems were not significant. In addition, peer victimization increased the odds of internalizing problems. Social services must be expended in low-income communities to effectively address peer victimization and substance use among urban African-American youth. (PsycINFO Database Record

Seabuckthorn Leaves Extract and Flavonoid Glycosides Extract from Seabuckthorn Leaves Ameliorates Adiposity, Hepatic Steatosis, Insulin Resistance, and Inflammation in Diet-Induced Obesity.

The aim of the current study was to elucidate the effect of seabuckthorn leaves (SL) extract and flavonoid glycosides extract from seabuckthorn leaves (SLG) on diet-induced obesity and related metabolic disturbances, and additionally, to identify whether flavonoid glycosides and other components in SL can exert a possible interaction for the prevention of metabolic diseases by comparing the effect of SL and SLG. C57BL/6J mice were fed a normal diet (ND, AIN-93G purified diet), high-fat diet (HFD, 60 kcal% fat), HFD + 1.8% (w/w) SL (SL), and HFD + 0.04% (w/w) SLG (SLG) for 12 weeks. In high fat-fed mice, SL and SLG decreased the adiposity by suppressing lipogenesis in adipose tissue, while increasing the energy expenditure. SL and SLG also improved hepatic steatosis by suppressing hepatic lipogenesis and lipid absorption, whilst also enhancing hepatic fatty acid oxidation, which may be linked to the improvement in dyslipidemia. Moreover, SL and SLG improved insulin sensitivity by suppressing the levels of plasma GIP that were modulated by secreted resistin and pro-inflammatory cytokine, and hepatic glucogenic enzyme activities. SL, especially its flavonoid glycosides (SLG), can protect against the deleterious effects of diet-induced obesity (DIO) and its metabolic complications such as adiposity, dyslipidemia, inflammation, hepatic steatosis, and insulin resistance.

Metabolic Effect of an Oriental Herbal Medicine on Obesity and Its Comorbidities with Transcriptional Responses in Diet-Induced Obese Mice.

Taeeumjowuitang (TJ) is an alternative herbal medicine that has been used to treat obesity in Korea. The molecular mechanisms involved in TJ-induced anti-obesity effects have not yet been determined. The aim of the current study was to elucidate the effects of TJ on obesity and metabolic syndrome, by analyzing the transcriptional and metabolic responses to TJ treatment. C57BL/6J mice were fed a high-fat or high-fat + 3% (w/w) TJ diet for 12 weeks. Their phenotypic characteristics were measured and the anti-obesity mechanism was elucidated, based on the RNA sequencing (RNA-seq) transcriptomic profiles in an animal model of obesity. TJ treatment ameliorated insulin resistance, dyslipidemia, and hepatic steatosis in high-fat diet-induced obese mice, with a simultaneous reduction in body weight gain by enhancing energy expenditure and suppressing adiposity. An analysis of the global transcriptional changes by RNA-seq revealed that TJ upregulated mitochondrial oxidative phosphorylation-associated genes in epididymal white adipose tissue (eWAT), suggesting an enhanced mitochondrial function after TJ treatment. Moreover, TJ effectively attenuated the high-fat diet-induced inflammatory response through transcriptional changes in eWAT. Our findings provide some mechanistic insights into the effects of TJ, an alternative oriental medicine, in the treatment of obesity and its comorbidities. They demonstrate that metabolic and transcriptional responses to diet-induced obesity with TJ treatment were desirable in adipose tissue metabolism.

Low-dose grape pomace and omija fruit extract is more effective than high-dose in lowering oxidative stress and fat-pad mass in db/db mice.

Previous studies have shown that the mixture of extracts of grape pomace and omija (GO) improved oxidative stress and obesity in mice. This study first investigated the dose-response effects of GO on oxidative stress and fat-pad mass. Male C57BL/KsJ-db/db mice were fed the following three experimental diets for 7 weeks: a normal control, high-dose grape pomace plus omija (HGO; 0.5% grape pomace plus 0.05% omija fruit, w/w), and low-dose grape pomace plus omija (LGO; 0.3% grape pomace plus 0.05% omija fruit, w/w). The LGO significantly decreased white adipose tissues weights, as well as ameliorated the plasma lipid profiles. The antioxidant effects of LGO led to a significant decrease in the erythrocytic H2O2 and thiobarbituric acid-reactive substance levels, while LGO increased erythrocytic antioxidant activities. These results suggest that LGO is more effective than HGO in lowering oxidative stress and body fat mass in db/db mice.